9,099 results found
    1. Microbiology and Infectious Disease

    eDNA-stimulated cell dispersion from Caulobacter crescentus biofilms upon oxygen limitation is dependent on a toxin–antitoxin system

    Cecile Berne, Sébastien Zappa, Yves V Brun
    Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.
    1. Biochemistry and Chemical Biology

    Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

    Ma Teresa Pellicer Martinez, Jason C Crack ... Nick E Le Brun
    Molecular details of how the iron–sulfur cluster cofactor of a bacterial global iron regulatory protein simultaneously senses iron and O2 are revealed by mass spectrometry and spectroscopy.
    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns, Huanjia Zhang ... Ryan Kerney
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Immunology and Inflammation
    2. Medicine

    Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury

    Daniel R Labuz, Giavonni Lewis ... Daniel T Leung
    Compared to non-burn tissue, T cells in burn tissue have a pro-inflammatory rather than a homeostatic tissue-resident phenotype, and unconventional T cells in burn tissue have a higher cytotoxic capacity.
    1. Neuroscience

    Pupillometry reveals perceptual differences that are tightly linked to autistic traits in typical adults

    Marco Turi, David Charles Burr, Paola Binda
    Pupil difference during bistable perception of bright and dark elements predicts autistic traits.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns, Jennifer S Avena ... Sue L Jaspersen
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Immunology and Inflammation
    2. Neuroscience

    Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

    Jeremy Carlos Burns, Bunny Cotleur ... Michael Mingueneau
    Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

    Anna L Miles, Stephen P Burr ... James A Nathan
    An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.
    1. Ecology
    2. Evolutionary Biology

    Multiple preferred escape trajectories are explained by a geometric model incorporating prey’s turn and predator attack endpoint

    Yuuki Kawabata, Hideyuki Akada ... Paolo Domenici
    The mathematical model incorporating new parameters explains multimodal distributions in escape direction (i.e., multiple preferred escape trajectories), which are previously observed in various animal taxa.
    1. Neuroscience

    Objective pupillometry shows that perceptual styles covary with autistic-like personality traits

    Chiara Tortelli, Marco Turi ... Paola Binda
    Pupillometry tracks individual differences linked with autistic traits independently of illusion susceptibility and perceptual reports.

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