A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.

Drosophila melanogastereven-skipped enhancers control transcriptional bursting by modulating frequency and amplitude, regardless of varying transcription factor inputs, even when mutated to express in embryonic regions not under selective pressure.

The dynamic current generated Na⁺/K⁺ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.

The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.

Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.

Cooperation enables burying beetles to outcompete flies and adapt to a wider range of temperatures as thermal generalists.

Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.

Direct measure of neural and hemodynamic activity in the developing human brain shows that the insula is a major source of transient bursting events that are critical for cortical maturation.