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The physical distance between genes in individual cells is the major factor driving co-transcriptional bursts, showing a significant degree of correlation for distances below 400 nm.

Analysis of genome integrity in primary murine B-cells reveals how depleting 26S proteasome activity enhanced cell survival following treatment with topoisomerase poisons.

Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.

Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.

In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.

An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.

The synthesis of multiple phosphoinositides function in an ordered pathway to promote recycling of some receptors to the plasma membrane.

Integrating an innovative community science platform with statistical modelling advances biodiversity monitoring and improves species habitat estimation across diverse taxa, supporting more effective conservation strategies.

TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.

By integrating theoretical and empirical approaches, the results show that linking abiotic factor and biotic interactions on the niche width will be critical for understanding species-specific responses to climate change.