The RNA-binding protein MSI1, which is required for stem cell and cancer cell proliferation in the brain and epithelial tissues, also directly senses the concentration of long non-esterified omega-9 fatty acids.
Mouse in vivo and in vitro analysis and human genetic screening highlight the role of anti-Müllerian hormone (AMH) signaling in GnRH neuronal development and function, and identify mutations in AMH and AMHR2 in CHH patients.
Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
Metabolic defects following expression of Aβ1-42 in nematode neurons are partially caused by inactivation of alpha-ketoglutarate dehydrogenase and can be rescued by Metformin.
A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.
In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.