2,425 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING

    Sytse J Piersma et al.
    Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
    1. Structural Biology and Molecular Biophysics

    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

    Sigrid Noreng et al.
    The in-depth structural and functional work provide a deeper understanding as to how the epithelial sodium channel is a heteromeric ion channel that is regulated by Na+ and proteolysis.
    1. Immunology and Inflammation

    Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Jaba Gamrekelashvili et al.
    Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.
    1. Neuroscience

    Temporal selectivity declines in the aging human auditory cortex

    Julia Erb et al.
    The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.
    1. Neuroscience

    The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

    Amy A Worth et al.
    The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.
    1. Developmental Biology

    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

    Saishu Yoshida et al.
    DYRK2 regulator governs the mammalian ciliogenesis to maintain proper embryogenesis via activation of the Hh signaling during development in vivo.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau et al.
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.
    1. Human Biology and Medicine
    2. Neuroscience

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis et al.
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    S-phase-independent silencing establishment in Saccharomyces cerevisiae

    Davis Goodnight, Jasper Rine
    Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.
    1. Microbiology and Infectious Disease

    Host sirtuin 2 as an immunotherapeutic target against tuberculosis

    Ashima Bhaskar et al.
    The inhibition of host Sirtuin-2 by AGK2 restricts mycobacterial growth in vivo by modulation of host transcriptome leading to activation of protective immune responses.

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