5,351 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

    Helen R McPherson et al.
    Fibrinogen, a key protein involved in blood coagulation, contains a disordered and previously poorly characterised region called αC that plays a critical role in fibrin fibre growth and clot stability.
    1. Developmental Biology

    A functional genetic toolbox for human tissue-derived organoids

    Dawei Sun et al.
    To facilitate human developmental biology research, CRISPR-mediated homologous recombination, tightly inducible gene knockdowns (CRISPRi) and overexpression (CRISPRa) have been efficiently applied to human organoids.
    1. Neuroscience

    Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb

    Shawn D Burton, Nathaniel N Urban
    Fast network oscillations in the mammalian main olfactory bulb emerge from the dense synchronization of gamma-frequency firing among resonant tufted cells.
    1. Immunology and Inflammation

    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Kotaro Akaki et al.
    Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.
    1. Cell Biology
    2. Developmental Biology

    SLC1A5 provides glutamine and asparagine necessary for bone development in mice

    Deepika Sharma et al.
    Osteoblasts utilize an elegant mechanism by which they obtain and subsequently synthesize the requisite amino acids to support osteoblast differentiation and bone formation.
    1. Neuroscience

    Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

    Taisuke Miyazaki et al.
    Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.
    1. Cancer Biology
    2. Cell Biology

    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

    Tomasz Radaszkiewicz et al.
    RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

    Zelin Liu et al.
    Accurate identification and quantification of various circRNA isoforms.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

    Seyi Falekun et al.
    Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
    1. Neuroscience

    NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

    Theresa Pohlkamp et al.
    Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.

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