44 results found
    1. Genetics and Genomics
    2. Neuroscience

    High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

    Qiaochu Li, Daniel-Cosmin Marcu ... Karl Emanuel Busch
    Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.
    1. Computational and Systems Biology
    2. Developmental Biology

    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

    Huan Liu, Kaylia Duncan ... Robert A Cornell
    Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Stem Cells and Regenerative Medicine

    External signals regulate continuous transcriptional states in hematopoietic stem cells

    Eva M Fast, Audrey Sporrij ... Leonard I Zon
    In vivo modulation of the prostaglandin, interferon, or granulocyte colony-stimulating factor pathway induces rapid and specific transcriptional changes in hematopoietic stem cells with significant heterogeneity in the cellular response.
    1. Developmental Biology
    2. Immunology and Inflammation

    Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

    Chew Leng Lim, Yu Zuan Or ... Valerie Chun Ling Lin
    Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.
    1. Immunology and Inflammation

    Amphibian mast cells serve as barriers to chytrid fungus infections

    Kelsey A Hauser, Christina N Garvey ... Leon Grayfer
    Enriching amphibian, Xenopus laevis, cutaneous mast cells confers protection against Batrachochytrium dendrobatidis chytrid fungus infections.
    1. Biochemistry and Chemical Biology

    A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

    Brennan J Wadsworth, Marina Leiwe ... Randall S Johnson
    The metabolite 2-hydroxybutyrate is an important aspect of exhaustion which leads to increased capacity in the branched chain amino acid degradation pathway.
    1. Immunology and Inflammation

    TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

    William D Jackson, Chiara Giacomassi ... Marina Botto
    A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors

    Damilola Pinheiro, Marie-Anne Mawhin ... Kevin J Woollard
    In-silico modeling of gene and protein emergence reveals how colony-stimulating factors contributed to the evolution and functional adaptions observed in mammalian neutrophils.
    1. Neuroscience

    Microtubule-dependent ribosome localization in C. elegans neurons

    Kentaro Noma, Alexandr Goncharov ... Yishi Jin
    The utility of split GFP for tissue-specific visualization of ribosomes in live Caenorhabditis elegans demonstrates the link between ribosomes and microtubules.

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