2 results found
    1. Cell Biology

    PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

    Stefania Monterisi, Miguel J Lobo ... Manuela Zaccolo
    The enzyme phosphodiesterase 2A2 localises at the mitochondrial membrane and its inhibition results in a local increase in cAMP concentration, mitochondrial elongation and resistance to apoptosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang, Yeong Hyeock Kim ... Jeong-Yoon Kim
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.

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