897 results found
  1. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Developmental Biology
    2. Neuroscience

    Revisiting the role of Dcc in visual system development with a novel eye clearing method

    Robin J Vigouroux et al.
    A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
    1. Evolutionary Biology

    The genetic architecture of gene expression levels in wild baboons

    Jenny Tung et al.
    RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

    Stephan Wilmes et al.
    IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
    1. Ecology

    Extinction risk and conservation of the world’s sharks and rays

    Nicholas K Dulvy et al.
    One-quarter of the Chondrichthyes have an elevated risk of extinction, mainly as a result of overfishing.
    1. Neuroscience

    Cortical magnification in human visual cortex parallels task performance around the visual field

    Noah C Benson et al.
    In humans, the surface area of early visual cortex across polar angle is distributed in a pattern that correlates strongly with radial asymmetries in behavioral performance on visual tasks.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

    Xiangrong Chen et al.
    Discovery and characterisation of a novel allosteric inhibitor-binding site in human Bloom syndrome protein.
    1. Cell Biology
    2. Plant Biology

    Delivery of endocytosed proteins to the cell–division plane requires change of pathway from recycling to secretion

    Sandra Richter et al.
    The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke et al.
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    1. Ecology
    2. Epidemiology and Global Health

    The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus

    Moritz UG Kraemer et al.
    The limits to the global distribution of the mosquitoes that transmit dengue and chikungunya have been predicted using a species distribution modelling approach.

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