Enhancing mitochondrial Ca²⁺ uptake effectively suppresses aberrant Ca²⁺ induced arrhythmogenic events in zebrafish, mouse and human cardiomyocytes, demonstrating a critical role for mitochondria in the regulation of cardiac rhythmicity.

The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.

Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.

Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.

The 3Å structure and correlated functional analysis of the TRPM2 cation channel from Nematostella vectensis shed light on the molecular mechanisms of TRPM2 regulation by intra- and extracellular Ca²⁺, and of inactivation of human TRPM2.

The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.

Cryo-EM structures of the gating cycle of bestrophin reveal the molecular underpinnings of activation and inactivation gating in this calcium-activated chloride channel and reveal a surprisingly wide pore.

A molecular investigation on the role of the peptide ligand inflorescence deficient in abscission (IDA) in regulating immunity and development during cell separation in Arabidopsis thaliana.

Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.

Cryo-EM structures reveal that MICU1-MICU2 operates like a regulatable toxin to block the pore of the mitochondrial calcium uniporter and confer Ca²⁺-dependent control.