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Cryo-EM structures of human MCU-EMRE-MICU1-MICU2 complex in the apo and Ca²⁺-bound states reveal how MICU1 and MICU2 impart their gating function to the mitochondrial calcium uniporter.

Structures of a TMEM16 phospholipid scramblase reveal that its Ca²⁺-dependent activation entails global conformational changes and how these rearrangements affect the membrane to enable transbilayer lipid transfer.

While activated by a common mechanism, both functions in TMEM16F - lipid scrambling and ion conduction - are likely mediated by alternate protein conformations that are at equilibrium in the ligand-bound state.

Cryogenic electron microscopy of the ryanodine receptor 1 at near-atomic resolution reveals a calcium-inactivated conformation and uncovers a conserved lipid-binding site.

Bespoke volumetric calcium imaging, validated with neuropixels recordings, evidence a population code for sound azimuth at the dorsal cortex of the inferior colliculus, with a contribution of noise correlations.

The hippocampal CA1 20–40 Hz rhythm is associated with nonspatial sequence memory processing and may contribute to the role of the hippocampus in processing temporal relationships among events.

In congenital stationary night blindness type 2, Ca_v3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Ca_v1.4 in cone synaptogenesis remains intact.

Temporally close events share a common timestamp regardless of the spatial context in which they occur.

Metabolic labelling and quantitative proteomics reveal the temporal evolution of cellular and neuronal responses to global activity manipulations.

A novel analytical framework for investigation of simultaneously occurring brain oscillations (from either single or multiple brain areas) and how it modulates the underlying neuronal population during sleep and wakefulness (or other behavioral tasks).