Phosphate and calcium from resorbing bone can find their way to the coronary circulation and contribute to atherosclerotic calcification of the blood vessels.
Gustavo A Gomez, Patrick Aghajanian ... Subburaman Mohan
Mouse molecular genetics and in vivo functional studies reveal that thyroid hormone is necessary for punctual proximal femur head development by a mechanism that differs temporally and molecularly from the secondary ossification center at the distal femur.
Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
Sarah M Rajtmajer, Timothy M Errington, Frank G Hillary
An increased emphasis on falsification – the direct testing of strong hypotheses – will lead to faster progress in science by allowing well-specified hypotheses to be eliminated.
Andrea Milzi, Enrico Domenico Lemma ... Mathias Burgmaier
Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.
Debashish Bhattacharya, Shobhit Agrawal ... Paul G Falkowski
The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.
Simone Bersini, Roberta Schulte ... Martin W Hetzer
Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
Alison M Devault, Tatum D Mortimer ... Caitlin S Pepperell
Mineralized placental tissue from Late Byzantine Troy enables the detailed reconstruction of genomes of mixed bacterial species responsible for maternal sepsis in the ancient world.
Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca2+]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.
A mechanism is proposed that allows investigators to study interventions to delay onset of heart disease in patients suffering from chronic inflammatory disease with bone loss.
