Michael Bucher, Stephan Niebling ... Marina Mikhaylova
Autism-associated SHANK3 missense mutations result in differential protein folding, stability, and intramolecular dynamics affecting its turnover at the synapse.
Intercellular interactions between fibrocytes and CD8+ T lymphocytes promote inflammation through a pathophysiological positive feedback loop in bronchi of patients with chronic obstructive pulmonary disease (COPD).
Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate DNA replication and, subsequently, cell division.
The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
Hua Leonhard Tan, Stefanie Bungert-Plümke ... Gabriel Stölting
The DCC-SMLM algorithm allows to determine protein oligomeric states in situ, using the information obtained from the colocalization of fluorescent markers, overcoming the need for extraction of proteins from cells or complicated experimental setups when using microscopy.
Brian C Del Rosario, Andrea J Kriz ... Jeannie T Lee
The chromosome architectural protein, CTCF, is phosphorylated at Ser224 in a cell-cycle-dependent manner and abrogation of phosphorylation leads to a cell growth defect.
Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.
Santi Mestre-Fos, Lucas Ferguson ... Jamie HD Cate
The extent of human eukaryotic translation initiation factor eIF3 interaction with the 3' ends of mRNA 3' untranslated regions (3'-UTRs) correlates with the level of translation.