1,128 results found
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

    Jefferson J Doyle et al.
    Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
    1. Cell Biology

    β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

    Ao Shen et al.
    FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Point of View: Looking back and looking forward at Janelia

    Gerald M Rubin, Erin K O'Shea
    The Janelia Research Campus opened its doors 12 years ago: we describe the philosophy underpinning Janelia, the lessons learned, and plans for the future.
    1. Biochemistry and Chemical Biology

    Ion Channels: Keeping a lid on calcium uptake

    Vivek Garg, Yuriy Kirichok
    Insight
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    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Cell Biology
    2. Ecology

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi et al.
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.

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