1,320 results found
    1. Computational and Systems Biology
    2. Neuroscience

    A functional model of adult dentate gyrus neurogenesis

    Olivia Gozel, Wulfram Gerstner
    The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
    1. Neuroscience

    Stability of neocortical synapses across sleep and wake states during the critical period in rats

    Brian A Cary, Gina G Turrigiano
    Sleep and wake states are not sufficient to drive changes in neocortical synaptic strengths.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Neuroscience

    Taste triggers a homeostatic temperature control in hungry flies

    Yujiro Umezaki, Sergio Hidalgo ... Fumika Hamada
    Hungry flies shifting from cooler to warmer temperature preferences in response to non-nutritive food indicates a taste-triggered response, similar to the cephalic phase response observed in mammals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular tweezer antagonizes seminal amyloids and HIV infection

    Edina Lump, Laura M Castellano ... Jan Münch
    CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The role of scaffold reshaping and disassembly in dynamin driven membrane fission

    Martina Pannuzzo, Zachary A McDargh, Markus Deserno
    Computational modeling of a dynamin-constricted membrane neck can rank proposed shape changes of the helical scaffold in terms of their fission aptitude and elucidate the associated pathways.
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey Hung-Chang Yao
    Revised
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    Updated
    • Important
    • Convincing
    1. Neuroscience

    Can sleep protect memories from catastrophic forgetting?

    Oscar C González, Yury Sokolov ... Maxim Bazhenov
    Computational modeling predicts that sleep replay plays a protective role against catastrophic forgetting by revealing synaptic mechanisms allowing overlapping populations of neurons to store multiple interfering memories.
    1. Physics of Living Systems

    Strong confinement of active microalgae leads to inversion of vortex flow and enhanced mixing

    Debasmita Mondal, Ameya G Prabhune ... Prerna Sharma
    Coupling between cell motility and strong confinement alters the force generators that cause flow fields to change their handedness and lead to enhanced mixing.
    1. Stem Cells and Regenerative Medicine

    ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

    Richard H Chapple, Tianyuan Hu ... Daisuke Nakada
    Estrogen is a systemic factor that promotes hematopoietic regeneration by activating the unfolded protein responses.

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