Catherine A Hartzell, Katarzyna I Jankowska ... Richard S Lewis
By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.
Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
Brian D Mueller, Sean A Merrill ... Erik M Jorgensen
The Caenorhabditis elegans presynapse contains two pools of synaptic vesicles at the active zone, coupled to either neuronal-type or muscle-type calcium channels, and to different docking machinery.
The small glycine residue in the Cav selectivity filter is an overlooked feature that determines Ca2+ selectivity and provides new insight into the Ca2+ selectivity mechanism conserved from prokaryotes to eukaryotes.
Karla Marie Márquez-Nogueras, Miryam Andrea Hortua Triana ... Silvia NJ Moreno
A transient receptor channel in Toxoplasma gondii that conducts calcium represents the first molecular element that initiates upstream calcium signals that activate parasite pathogenic pathways.
Georgia Panagiotakos, Christos Haveles ... Ricardo E Dolmetsch
The Timothy syndrome mutation in Cav1.2 gives rise to defects in neuronal differentiation by preventing a developmental switch in channel splicing and elevating calcium signaling in differentiating cells.
Xiaowei Hou, Shana R Burstein, Stephen Barstow Long
The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.
David B Halling, Ashley E Philpo, Richard W Aldrich
Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.
Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
The feedback inhibition of T-type calcium channels by intracellular calcium provides new avenues to better decipher the roles of these low-voltage-activated channels in the fine control of calcium signaling events in physiology and pathophysiology.
