2,204 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The discriminatory power of the T cell receptor

    Johannes Pettmann et al.
    The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.
    1. Neuroscience

    Uncovering a ‘sensitive window’ of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings

    Jasmien Orije et al.
    Despite the structural sexual dimorphism in the song control system, both male and female starlings experience similar seasonal neuroplasticity in multisensory systems and cerebellum during the photosensitive phase, which acts as a sensitive window of plasticity.
    1. Medicine

    Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

    Nicole Aaron et al.
    Adipsin, the oldest known adipokine, has a novel role as a a regulator of bone marrow fat and, consequently, overall bone health.
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg et al.
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Microbiology and Infectious Disease

    Calcium signaling through a transient receptor channel is important for Toxoplasma gondii growth

    Karla Marie Márquez-Nogueras et al.
    A transient receptor channel in Toxoplasma gondii that conducts calcium represents the first molecular element that initiates upstream calcium signals that activate parasite pathogenic pathways.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

    Máté Nászai et al.
    Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
    1. Neuroscience

    Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

    Laifu Li et al.
    Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu et al.
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Cell Biology

    Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

    Stephanie E Crilly et al.
    A GPCR activated by the same agonist engages different conformational biosensors at different subcellular locations, suggesting that location-based conformations drive spatial encoding of signaling.

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