677 results found
    1. Plant Biology

    Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

    Benjamin Brandt et al.
    The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Ion channels and calcium signaling in motile cilia

    Julia F Doerner et al.
    Direct patch clamp of ependymal motile cilia reveals that voltage-gated calcium channels in the cell body dominate their electrical and calcium signaling properties.
    1. Immunology and Inflammation
    2. Cell Biology

    Calcium-mediated shaping of naive CD4 T-cell phenotype and function

    Vincent Guichard et al.
    Calcium-calcineurin signaling cascade drives the acquisition of both the phenotype of the most self-reactive naive CD4 T cells and their enhanced cell-intrinsic ability to commit into induced regulatory T cells upon activation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Neuroscience

    Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium

    Stephanie C Gantz et al.
    The loss of calcium-dependent D2 autoreceptor desensitization caused by prior in vivo cocaine exposure may be conferred by an unexpected role of the D2L splice variant as an autoreceptor.
    1. Genes and Chromosomes
    2. Human Biology and Medicine

    A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

    Jefferson J Doyle et al.
    Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Cell Biology
    2. Neuroscience

    A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission

    Gilles Ouanounou et al.
    Skeletal muscle cells constantly monitor their own activity and that of their partner neuron at synapses, enabling them to provide the neuron with feedback regarding neurotransmitter release.
    1. Biochemistry and Chemical Biology

    Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

    Patrick J Nygren et al.
    Flexibility is a defining feature of AKAP kinase-phosphatase assemblies and points toward a mechanism whereby combinatorial recruitment of binding partners tailors the overall conformation of the macromolecular assembly, allowing customized physiological roles.

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