19 results found
    1. Structural Biology and Molecular Biophysics

    Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

    Rose E Dixon et al.
    The Ca2+-driven functional coupling of CaV1.2 channels is a mechanism of channel memory that may modulate the amplification of Ca2+ influx.
    1. Cell Biology
    2. Neuroscience

    Activity and Ca2+ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons

    Eric N Senning, Sharona E Gordon
    Channel activity is a novel regulatory mechanism for channel mobility in the plasma membrane.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: Poring over furrows

    Skylar ID Fisher, H Criss Hartzell
    Cryo-electron microscopy reveals the structure of a chloride channel that is closely related to a protein that transports lipids.
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    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet et al.
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A molecular filter for the cnidarian stinging response

    Keiko Weir et al.
    Cnidarian stinging cells use a specialized voltage-gated calcium channel to integrate distinct sensory signals and selectively trigger a predatory response.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

    Claudia M Moreno et al.
    CaV1.3 channels of the short isoform are coupled via their C-terminal domains in a Ca2+-CaM-dependent manner, which facilitates Ca2+ influx and increases the discharge of hippocampal neurons.
    1. Structural Biology and Molecular Biophysics

    Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

    Oscar Vivas et al.
    Super-resolution imaging reveals a novel multi-channel arrangement that explains how big potassium (BK) channel activation closely tracks the opening of low-voltage-activated L-type calcium channels.
    1. Cell Biology
    2. Plant Biology

    Reticulon proteins modulate autophagy of the endoplasmic reticulum in maize endosperm

    Xiaoguo Zhang et al.
    Plant reticulons bind Atg8 under ER stress to promote reticulophagy and ameliorate ER stress in the maize endosperm.
    1. Cell Biology
    2. Immunology and Inflammation

    Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

    Tobias X Dong et al.
    Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.
    1. Neuroscience

    EM connectomics reveals axonal target variation in a sequence-generating network

    Jörgen Kornfeld et al.
    Combining light microscopy and electron microscopy uncovered patterns of neural connectivity in a zebra finch forebrain region capable of generating song-related sequential activity, contributing to our understanding of the neural circuitry that underlies skilled motor performance.

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