569 results found
    1. Neuroscience

    Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity

    Scott L Jones et al.
    The activation of small-conductance calcium-activated potassium channels in spines by action potentials regulates the induction of spike-timing dependent synaptic plasticity during low-frequency single action potential–EPSP pairing.
    1. Computational and Systems Biology
    2. Neuroscience

    Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

    Daniel B Dorman et al.
    Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.
    1. Neuroscience

    High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion

    Valerio Francioni et al.
    Layer 5 neuron apical tuft in mouse visual cortex display widespread, highly correlated calcium signals, with a strong and asymmetric coupling to somatic signals, independent of visual stimulation and locomotion.
    1. Neuroscience

    Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

    Farzaneh Najafi et al.
    Sensory-driven calcium spikes in Purkinje cells are not binary; instead, they are graded and can provide information about the strength of a periocular airpuff stimulus known to drive learning.
    1. Ecology
    2. Plant Biology

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Structural Biology and Molecular Biophysics

    Ion Channels: Poring over furrows

    Skylar ID Fisher, H Criss Hartzell
    Cryo-electron microscopy reveals the structure of a chloride channel that is closely related to a protein that transports lipids.
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    1. Cell Biology
    2. Neuroscience

    Neuroscience: Endocytosis gets in tune with action potential bursts

    Melissa A Herman, Christian Rosenmund
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    1. Neuroscience

    Functional clustering of dendritic activity during decision-making

    Aaron Kerlin et al.
    In motor cortex pyramidal neurons, diverse task-related signals are distributed throughout the dendritic arbor and compartmentalized by dendritic distance and branching.
    1. Human Biology and Medicine

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.

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