373 results found
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

    Ivan Kadurin et al.
    Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.
    1. Neuroscience

    Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking

    Jillian N Pearring et al.
    Rather than relying on intrinsic intracellular targeting information, the key phototransduction enzyme guanylate cyclase 1 is delivered to the photosensory cilium with the visual pigment rhodopsin.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Cell Biology

    Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

    Muqing Cao et al.
    During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
    1. Neuroscience

    ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans

    Kelly H Oh et al.
    An endoplasmic reticulum membrane protein regulates synaptic transmission, alcohol sensitivity, and gene expression by controlling the trafficking of a calcium-activated potassium channel.
    1. Evolutionary Biology
    2. Neuroscience

    Physiological constraint on acrobatic courtship behavior underlies rapid sympatric speciation in bearded manakins

    Meredith C Miles et al.
    Skeletal muscle performance sets the course of rapid speciation by defining the evolutionary trajectory of reproductive behavior.
    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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    1. Biochemistry and Chemical Biology

    Cytokines: Revealing the secrets of secretion

    Antony Galione, Lianne C Davis
    An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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    1. Developmental Biology

    The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling

    Manon Destalminil-Letourneau et al.
    Two niches contribute to the control of Drosophila blood cell homeostasis through their differential regulation of hematopoietic progenitors.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.

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