927 results found
    1. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
    1. Biochemistry and Chemical Biology

    Ion Channels: Keeping a lid on calcium uptake

    Vivek Garg, Yuriy Kirichok
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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis

    Michael Taschner et al.
    CRISPR/Cas knockout of intraflagellar transport protein 80 shows that this subunit is absolutely required for ciliogenesis, and biophysical studies reveal that this protein may dimerize the intraflagellar transport complex.
    1. Neuroscience

    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

    Jeong Hyang Park et al.
    Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu et al.
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips et al.
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.
    1. Biochemistry and Chemical Biology

    Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

    Ming-Feng Tsai et al.
    Studies of EMRE, one of the four essential protein subunits in the mitochondrial calcium uniporter complex that regulates calcium ion levels in mitochondria, reveal new details about the physical interactions between the subunits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A recombinant BBSome core complex and how it interacts with ciliary cargo

    Björn Udo Klink et al.
    Six BBS proteins form a core BBSome transport vehicle, which is sufficient for recognizing membrane proteins for transport into the ciliary compartment.
    1. Cell Biology

    Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding

    Muqing Cao et al.
    During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou et al.
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

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