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    1. Neuroscience

    Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

    Pascal Branchereau et al.
    Electrophysiological and simulation approaches show that a chloride-related longer relaxation of the inhibitory synaptic events partially compensates the early defect in the chloride homeostasis detected in fetal SOD spinal motoneurons.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Structural Biology and Molecular Biophysics

    Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

    Celso M Teixeira-Duarte et al.
    Cations are essential cofactors in the ATP activation mechanism of the KtrAB cation channel and appear to be cofactors of many other nucleotide-dependent RCK domains.
    1. Neuroscience

    Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity

    Vanessa Plantier et al.
    Calpain is a promising therapeutic target to reduce spasticity after a spinal cord injury.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

    Keisuke Kitakaze et al.
    Cell-based high-throughput screening identifies IBT21 as a chemical chaperone, that inhibits ER protein aggregation and prevents the cell death caused by a proteotoxin, the aggregation-prone prion protein.
    1. Neuroscience

    The computation of directional selectivity in the Drosophila OFF motion pathway

    Eyal Gruntman et al.
    ON and OFF visual motion is computed with the same algorithm despite differences in circuit architecture.
    1. Cell Biology
    2. Human Biology and Medicine

    Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

    King Faisal Yambire et al.
    Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
    1. Microbiology and Infectious Disease

    Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa

    Dominique H Limoli et al.
    Pseudomonas aeruginosa coordinates invasion and destruction of Staphylococcus aureus communities by modulating single-cell and collective motility.
    1. Structural Biology and Molecular Biophysics

    Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

    Marina A Kasimova et al.
    The gating polarity of a voltage-gated ion channel is primarily determined by turn propensity of residues at a critical position in the middle of the S4 voltage-sensing helix.
    1. Neuroscience

    Reliability of an interneuron response depends on an integrated sensory state

    May Dobosiewicz et al.
    A pair of interneurons in C. elegans condenses information from multiple sensory neurons into a uniform response, using an AND-gate logic to represent a stimulus with positive valence.