182 results found
    1. Structural Biology and Molecular Biophysics

    Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

    Rose E Dixon et al.
    The Ca2+-driven functional coupling of CaV1.2 channels is a mechanism of channel memory that may modulate the amplification of Ca2+ influx.
    1. Biochemistry and Chemical Biology

    Regulation of mTORC1 by lysosomal calcium and calmodulin

    Ruo-Jing Li et al.
    The multipronged chemical biology approach unraveled a novel mechanism by which mTOR is regulated by the second messenger calcium.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

    Sohum Mehta et al.
    The ability of calcium waves to exert different effects on calcineurin activity depending on subcellular location is mediated by the distribution of calmodulin.
    1. Structural Biology and Molecular Biophysics

    Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

    Jacqueline Niu et al.
    Two structurally-unrelated regulatory proteins utilize parallel molecular mechanisms to selectively tune calcium and calmodulin feedback of calcium and sodium ion channels and reveals a novel strategy to engineer synthetic channel modulators.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya et al.
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity

    Jun Qin et al.
    Genetic and biochemical analyses reveal a virulence mechanism employed by V. dahliae that involves inhibition of the transcription factor activity of CBP60g and SARD1.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

    Nan Liu et al.
    C-terminus mediated inhibition is one emerging modality of intervention for L-type Ca2+ channels, which coordinate multiple motifs to acutely tune Ca2+ current and Ca2+ influx down to the lower limits preset by end-stage Ca2+-dependent inactivation.
    1. Cell Biology
    2. Plant Biology

    Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

    Juan Tian et al.
    Kinesin-like calmodulin-binding protein integrates microtubules and F-actin to assemble the cytoskeletal configuration needed for trichome formation.
    1. Physics of Living Systems

    Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

    Fabian Baumann et al.
    Atomic force microscopy based single-molecule force spectroscopy of smooth muscle myosin light chain kinase strongly indicates the existence of a mechanically triggerable activation pathway analogous to its well-established biochemical regulation pathway via calcium-loaded calmodulin.

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