117 results found
    1. Neuroscience

    A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

    Sharon R Ladyman et al.
    Despite voluntary exercise being rewarding to mice, pregnancy hormones act in the maternal brain to markedly reduce the time females choose to engage in this activity.
    1. Genetics and Genomics
    2. Neuroscience

    Neuronal calmodulin levels are controlled by CAMTA transcription factors

    Thanh Thi Vuong-Brender et al.
    CAMTA transcription factors are evolutionarily conserved regulators of neuronal levels of the major Ca2+ sensor calmodulin.
    1. Cell Biology
    2. Neuroscience

    The amyloid precursor protein is a conserved Wnt receptor

    Tengyuan Liu et al.
    The amyloid precursor protein known for its role in causing familial Alzheimer's disease directly interacts with secreted proteins, called Wnts, known for their key roles in brain development and homeostasis, suggesting the two processes may be directly linked.
    1. Neuroscience

    Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

    Trygve E Bakken et al.
    Transcriptomic differences between relay neurons in the mature mammalian dLGN are subtle relative to striking differences in morphology and cortical projection targets.
    1. Neuroscience

    Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

    Sahana Sitaraman et al.
    A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.
    1. Neuroscience

    Long-term stability of cortical ensembles

    Jesús Pérez-Ortega et al.
    Spontaneous and visually evoked neuronal ensembles in mouse visual cortex can last for weeks, potentially supporting the long-lasting representation of perceptions and memories.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Autoregulatory control of microtubule binding in doublecortin-like kinase 1

    Regina L Agulto et al.
    Doublecortin-like kinase 1 modulates its own kinase activity to tune its microtubule-binding affinity, providing molecular insights into a unique form of autoregulatory control over microtubule-binding activity.
    1. Neuroscience

    Sensory coding and the causal impact of mouse cortex in a visual decision

    Peter Zatka-Haas et al.
    Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Cell Biology
    2. Neuroscience

    Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

    Georgina Kontou et al.
    Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.

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