54 results found
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang et al.
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Genetics and Genomics

    Genetic and environmental perturbations lead to regulatory decoherence

    Amanda Lea et al.
    Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
    1. Neuroscience

    VEGF signaling regulates the fate of obstructed capillaries in mouse cortex

    Patrick Reeson et al.
    Mapping the fate of clogged brain capillaries reveals that VEGF signaling plays a critical role in dictating whether capillaries regain blood flow and persist or are pruned from the vascular tree.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
  1. Research: Publication bias and the canonization of false facts

    Silas Boye Nissen et al.
    Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
    1. Evolutionary Biology

    Phenotypic plasticity as a mechanism of cave colonization and adaptation

    Helena Bilandžija et al.
    Astyanax mexicanus surface-dwelling fish exposed to complete darkness develop many traits resembling cavefish adaptations by phenotypic plasticity in a single generation.
    1. Plant Biology

    The role of APETALA1 in petal number robustness

    Marie Monniaux et al.
    Variable petal number in Cardamine hirsuta is explained by regulatory changes in the MADS-box gene APETALA1 that relaxed its epistasis over mapped QTL in the C. hirsuta genome.
    1. Neuroscience

    Impaired adaptation of learning to contingency volatility in internalizing psychopathology

    Christopher Gagne et al.
    Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Fast and flexible estimation of effective migration surfaces

    Joseph Marcus et al.
    Fast and flexible estimation of effective migration surfaces (FEEMS) is a new statistical method that can quickly infer and visualize patterns of migration from genetic data with spatial coordinates.
    1. Immunology and Inflammation

    Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria

    Elizabeth H Aitken et al.
    Machine learning identified six protective antibody features and showed for the first time that serological markers can predict protection from placental-malaria, which is important for evaluation and development of vaccines.

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