2,325 results found
    1. Cancer Biology
    2. Cell Biology

    Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

    William Putzbach et al.
    Loading of CD95 and CD95L-derived sequences into the RNA-induced silencing complex elicits a distinct form of RNAi-mediated cell death of cancer cells that results from the targeting of multiple survival genes.
    1. Human Biology and Medicine

    Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

    S Michael Rothenberg et al.
    SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.
    1. Cell Biology
    2. Human Biology and Medicine

    A kinase-independent function of AKT promotes cancer cell survival

    Igor Vivanco et al.
    The oncogenic potential of the serine threonine kinase AKT is not exclusively dependent on catalytic activity, but also involves the non-catalytic function of the pleckstrin homology domain.
    1. Cancer Biology

    SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

    Ziling Fang et al.
    SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel et al.
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Peter L Freddolino et al.
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Nataly Shtraizent et al.
    Mannose phosphate isomerase is a metabolic enzyme regulating cell survival in both embryonic and cancer cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

    Justin M Jenson et al.
    Short peptides that bind tightly to anti-apoptotic protein Bfl-1 but not other Bcl-2 family members provide a tool for diagnosing cancer cell survival mechanisms and a lead for developing new therapeutics.

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