Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.

Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?

Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.

Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.

Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.

The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.

The National Institutes of Health needs to make radical changes to ensure that biomedical research continues to thrive in the United States.

The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.

The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.

Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.