Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?

Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.

Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.

The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.

The National Institutes of Health needs to make radical changes to ensure that biomedical research continues to thrive in the United States.

The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.

Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.

A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.

Controlled neo-glycosylation of antigens can influence intracellular routing of antigens and the nature and strength of immune response, and should therefore be considered as a major determinant in the design of vaccines against cancer and infectious diseases.

Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.