126 results found
    1. Cancer Biology

    SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

    Maurizio Fazio et al.
    A genetic discovery screen for epigenetic factors accelerating melanoma development in vivo identifies SATB2 as a driver of tumor invasion and resistance to FDA-approved BRAF-targeted inhibitor Vemurafenib.
    1. Immunology and Inflammation

    Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

    Marie Marotel et al.
    Similar to T cell exhaustion, natural killer cell dysfunction in chronic hepatitis B patients results from deregulated calcium pathway.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

    Jack Alfred Bryant et al.
    Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
    1. Neuroscience

    Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline

    Quanjing Chen et al.
    Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.
    1. Cancer Biology

    Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

    Richard Lee Barrett, Ellen Puré
    Long under-appreciated, fibroblast biology is a key aspect of understanding how the immune system responds to tumors and may hold the key to improving immunotherapy in this tricky space.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

    Yiska Weisblum et al.
    SARS-CoV-2 spike variants that resist neutralization by therapeutic antibodies or convalescent plasma can be generated in the laboratory and exist at low frequency in natural populations.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Cytotoxic T cells swarm by homotypic chemokine signalling

    Jorge Luis Galeano Niño et al.
    Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.
    1. Cancer Biology
    2. Immunology and Inflammation

    The effects of age and systemic metabolism on anti-tumor T cell responses

    Jefte M Drijvers et al.
    A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8+ T cell function, anti-tumor immunity, and immunotherapy responsiveness.

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