1,977 results found
    1. Neuroscience

    Mechanisms of competitive selection: A canonical neural circuit framework

    Shreesh P Mysore, Ninad B Kothari
    A first principles, neuro-computational framework proposes a path for the experimental dissection of neural circuit mechanisms of competitive selection across brain areas and animal species.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub et al.
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Developmental Biology

    Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

    Laura E Kuil et al.
    Embryonic and definitive macrophages require colony-stimulating factor 1 receptor, whereas non-hematopoietic metaphocytes that resemble macrophages do not, explaining the relative high numbers of putative macrophages in Csf1r-deficient zebrafish.
    1. Developmental Biology
    2. Immunology and Inflammation

    A single-cell survey of Drosophila blood

    Sudhir Gopal Tattikota et al.
    Single-cell RNA sequencing of Drosophila hemocytes in blood distinguishes various states within known blood cell types and implicates a novel role for fibroblast growth factor receptor signaling in inter-hemocyte crosstalk.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

    Mounir El Maï et al.
    Telomere shortening with age promotes a switch from p53-dependent apoptosis to senescence prompted by tissue damage that triggers conflicting mTOR/AKT signalling, lower OxPhos defences and ROS, mitochondria dysfunction and senescence.
    1. Structural Biology and Molecular Biophysics

    Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

    Charles E MacKay et al.
    PKD2 (polycystin-2) channels are a major component of a flow-sensing signaling mechanism in endothelial cells that stimulates vasodilation and reduces blood pressure.
    1. Neuroscience

    Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice

    Sheila Hoffmann-Conaway et al.
    The presynaptic scaffolding protein Bassoon is involved in regulating neurotransmitter release by controlling synaptic vesicle pool size and vesicular protein turnover through increased ubiquitination and Parkin-dependent autophagy.
    1. Neuroscience

    The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

    Beatriz Alvarez-Castelao et al.
    In neurons, inhibition of the proteasome results in feedback inhibition of protein synthesis, mediated by heme-regulated kinase 1, which is optimized to act as both a sensor and an effector.

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