2,532 results found
    1. Cancer Biology

    Limited inhibition of multiple nodes in a driver network blocks metastasis

    Ali Ekrem Yesilkanal et al.
    Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
    1. Neuroscience

    Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

    Zachariah Bertels et al.
    In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
    1. Biochemistry and Chemical Biology

    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

    Renata O Pereira et al.
    Lack of OPA1 in BAT impairs its thermogenic activation and induces endoplasmic reticulum stress, while improving systemic metabolism and thermoregulation via ATF4-FGF21-dependent and -independent mechanisms.
    1. Cell Biology

    Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

    Guangfeng Geng et al.
    Fundc1-mediated mitophagy protects renal EPO-producing cells from myofibroblastic conversion under stresses.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

    Zachary Clemens et al.
    Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
    1. Cell Biology

    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

    Stéphanie Torrino et al.
    UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
    1. Medicine

    Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

    Salwa Naushin et al.
    Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.
    1. Genetics and Genomics
    2. Neuroscience

    Propensity for somatic expansion increases over the course of life in Huntington disease

    Radhia Kacher et al.
    Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
    1. Epidemiology and Global Health

    Sex differences in biological aging with a focus on human studies

    Sara Hägg, Juulia Jylhävä
    Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
    1. Physics of Living Systems

    Optimal evolutionary decision-making to store immune memory

    Oskar H Schnaack, Armita Nourmohammad
    Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.

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