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    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Reactive Oxygen Detoxification Contributes to Mycobacterium abscessus Antibiotic Survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

    Hilda Tateossian, Amy Southern ... Steve DM Brown
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology

    Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
    Membrane atg8ylation but not canonical autophagy control retromer-dependent endosomal sorting of cargo, including glucose transporter GLUT1, of general import and of significance for control of tuberculosis.
    1. Cell Biology

    ACVR2A Facilitates Trophoblast Cell Invasion through TCF7/c-JUN Pathway in Pre-eclampsia Progression

    Shujing Yang, Huanyao Liu ... Fang He
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Cancer Biology

    Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

    Timothy J Abreo, Emma C Thompson ... Edward C Cooper
    A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition

    Praver Gupta, Sayantani Kayal ... Tamal Das
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Epidemiology and Global Health

    A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index

    Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Medicine
    2. Microbiology and Infectious Disease

    The effect of combining antibiotics on resistance: A systematic review and meta-analysis

    Berit Siedentop, Viacheslav N Kachalov ... Sebastian Bonhoeffer
    A systematic review shows no evidence of harm or benefit of antibiotic combinations on resistance evolution as clinical data lack statistical power to draw definitive conclusions, highlighting a knowledge gap.
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