A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.

Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.

Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.

Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.

EB1 targeting to growing microtubule plus-ends is facilitated by tapered microtubule tip structures.

Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.

Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.

Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.

Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.

A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.