Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.

Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.

The multiple component mechanisms of extra-classical receptive field modulation, with distinct dynamics, discovered in the monkey visual cortex have important implications for understanding contextual perceptual processing.

Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.

Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.

Newly formed tetraploid cells rapidly lose extra centrosomes acquired upon tetraploidization via asymmetric centrosome clustering during cell division and selective advantage of tetraploid daughter cells that inherit a single centrosome.

Evidence suggests that the oskar gene, a critical germ line determinant in insects, was formed by fusion of bacterial and eukaryotic sequences at least 450 million years ago.

Nodal signaling regulates gastrulation cell behaviors largely in parallel with planar cell polarity signaling and is sufficient for ex vivo extension of embryonic explants.