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    1. Cancer Biology

    Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

    Ruijing Tang, Luobin Guo ... Xiaolong Liu
    ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
    1. Epidemiology and Global Health

    A review of HPV and HBV vaccine hesitancy, intention, and uptake in the era of social media and COVID-19

    Emily K Vraga, Sonya S Brady ... Shalini Kulasingam
    A review of the current empirical literature underscores the need for longitudinal research examining potential spillover effects between hesitancy, intention, or uptake for the COVID vaccine and HPV and HBV vaccines, especially to account for social media misinformation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

    Matheswaran Kandasamy, Uzi Gileadi ... Vincenzo Cerundolo
    Immunization with NY-ESO-1 S-FLU virus elicits a robust NY-ESO-1-specific CTL response and suppresses the NY-ESO-1-expressing tumour development and spontaneous metastasis.
    1. Medicine
    2. Neuroscience

    Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

    Jörn Lötsch, Khayal Gasimli ... Marco Sisignano
    Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Cancer Biology

    Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

    Aojia Zhuang, Aobo Zhuang ... Chen Ding
    Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
    1. Immunology and Inflammation

    Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

    Claudio Tripodo, Barbara Bassani ... Sabina Sangaletti
    Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias, Wojciech Fendler ... Dipanjan Chowdhury
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand
    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
    1. Epidemiology and Global Health

    Point of View: COVID-19 as a catalyst for reimagining cervical cancer prevention

    Rebecca Luckett, Sarah Feldman ... Suzanne Garland
    The Policy Committee of the International Papillomavirus Society describes how lessons learnt from the COVID-19 pandemic could propel a new approach to the elimination of cervical cancer that is more likely to be successful.