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Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
Friederike Elisabeth Kohrs et al.
Genetics and Genomics
sustains trans-synaptic BMP signaling required for synaptic maintenance with age
Jessica M Sidisky et al.
Maintaining synaptic structure and function over time requires continuous signaling from pathways that are crucial for synapse development.
Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis
Mamoru Ishii et al.
Live-cell imaging and mathematical modeling reveal the physical basis of collective cell migration underlying spiral cochlear duct formation during murine inner ear development.
Living Science: Truth even unto its innermost parts
Challenging anyone who spreads falsehoods is an important part of respecting the truth in both science and the wider world.
Genetics and Genomics
Emergence and diversification of a highly invasive chestnut pathogen lineage across southeastern Europe
Lea Stauber et al.
The chestnut blight fungus has successfully established an intermediary, diverse European bridgehead population, giving rise to a highly invasive clonal lineage spreading across southeastern Europe.
Chromosomes and Gene Expression
Computational and Systems Biology
Effective dynamics of nucleosome configurations at the yeast
Michael Roland Wolff et al.
Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring and functional determinants
J Roman Arguello et al.
Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses
Aaron J Norris et al.
Warm-activated parabrachial neurons contain overlapping dynorphin and enkephalin expressing subpopulations, project to preoptic hypothalamus, and mediate behavioral and physiological thermal defenses behaviors.
One-shot analysis of translated mammalian lncRNAs with AHARIBO
Luca Minati et al.
Detection of translated lncRNAs through selective isolation of active ribosomes, ribosome-associated RNAs and corresponding de novo synthesised peptides.
Developmental hourglass and heterochronic shifts in fin and limb development
Koh Onimaru et al.
Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
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