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    1. Cancer Biology

    MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

    Renumathy Dhanasekaran et al.
    MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel et al.
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Cancer Biology

    Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

    Angela M Halstead et al.
    Bladder-cancer-associated RXRA mutations were found to stimulate urothelial proliferation through a mechanism susceptible to small molecule inhibitors of Peroxisome Proliferator-Activated Receptors, credentialing a new class of targetable drivers of bladder cancer.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

    Sakari Vanharanta et al.
    Inactivation of a multifunctional RNA-binding protein can lead to the acquisition of pro-metastatic phenotypes, possibly by stabilizing large-scale transcriptomic changes that provide a selective advantage during cancer progression.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

    Thomas K Ni, Charlotte Kuperwasser
    The study of a recurrent breast cancer MAGI3 truncation reveals the role of MAGI3 in regulating the Hippo effector YAP and highlights premature mRNA cleavage and polyadenylation as a mechanism underlying cancer development.
    1. Cancer Biology
    2. Genetics and Genomics

    Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

    Timour Baslan et al.
    Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
    1. Cancer Biology
    2. Immunology and Inflammation

    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

    Andrea Walens et al.
    CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.