70 results found
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese et al.
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

    Ryan M McCormack et al.
    Perforin-2 deficiency is lethal upon infection with pathogenic bacteria despite the presence of other bactericidal effectors.
    1. Ecology

    First bone-cracking dog coprolites provide new insight into bone consumption in Borophagus and their unique ecological niche

    Xiaoming Wang et al.
    Fossilized feces (coprolites) of extinct bone-crushing dogs, Borophagus parvus, from late Miocene (6 million years ago) of California demonstrates consumption and preservation of bones in digestive tracts and potential social hunting behavior by these predators.
    1. Genetics and Genomics

    Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

    Benoit Ballester et al.
    Combinatorial transcription factor binding shared by multiple species enriches for essential biological pathways and coincides with disease-causing regulatory DNA mutations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio et al.
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Developmental Biology
    2. Evolutionary Biology

    Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

    Judith Wexler et al.
    Sexual differentiation controlled by sex-specific mRNA splicing evolved in a step-wise manner in insects.
    1. Evolutionary Biology

    A multidisciplinary approach to a unique palaeolithic human ichnological record from Italy (Bàsura Cave)

    Marco Romano et al.
    Traces of crawling locomotion, including children younger than 3 years old, are documented for the first time in the global human ichnological record.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang et al.
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Genetics and Genomics

    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

    Daniel Wells et al.
    ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.

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