25 results found
    1. Neuroscience

    Sex-dependent effects of in utero cannabinoid exposure on cortical function

    Anissa Bara et al.
    Adult male, but not female, rats showed altered neuronal function, inhibited synaptic plasticity and diminished social behavior following cannabinoid exposure during gestation in a model of cannabis use during pregnancy.
    1. Medicine
    2. Neuroscience

    Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

    Alejandra Escudero-Lara et al.
    A mouse model of endometriosis reveals that moderate doses of Δ9-tetrahydrocannabinol produce clear regression of ectopic endometrial growths, pronounced alleviation of pelvic pain and unexpected memory improvements.
    1. Neuroscience

    Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

    Cristina Blázquez et al.
    Δ9-Tetrahydrocannabinol impairs motor coordination in mice by inhibiting autophagy in the striatonigral pathway, thus defining a new conceptual view of how cannabis acts in the brain.
    1. Neuroscience

    Sex Difference: What does cannabis do to the brain before birth?

    Stefano Musardo, Camilla Bellone
    Being exposed to cannabinoids in the womb has different consequences for male and female rats. .
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    1. Developmental Biology
    2. Neuroscience

    Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

    Alexandre B Roland et al.
    Cannabinoids inhibit neuronal expansion and growth through the rapid contraction of actomyosin.
    1. Structural Biology and Molecular Biophysics

    Cannabidiol interactions with voltage-gated sodium channels

    Lily Goodyer Sait et al.
    The high resolution crystal structure and electrophysiology of a sodium channel complex with cannabidiol, a drug approved for treatment of severe epilepsies, demonstrate the basis for its structural- functional effects.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism of TRPV2 channel modulation by cannabidiol

    Ruth A Pumroy et al.
    Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.
    1. Neuroscience

    The relationship between spatial configuration and functional connectivity of brain regions

    Janine Diane Bijsterbosch et al.
    Connectivity network matrices, as estimated with masking or dual regression against group-level parcellations, reflect little or no unique cross-subject information that is not also captured by spatial topographical variability.
    1. Genetics and Genomics

    DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

    Eilis Hannon et al.
    DNA methylation data can be harnessed to provide insights into molecular and phenotypic differences associated with the spectrum of psychosis diagnoses.
    1. Genetics and Genomics

    Polygenic Scores: It is time to get real when trying to predict educational performance

    Cecile Janssens
    A study of 3,500 children in the UK shows that data on socioeconomic background and previous educational achievements can better predict how students will perform at school than genetic data.
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