276 results found
    1. Neuroscience

    More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction

    Baoqiang Li et al.
    Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
    1. Developmental Biology
    2. Neuroscience

    A novel perivascular cell population in the zebrafish brain

    Marina Venero Galanternik et al.
    A new brain perivascular cell type in the zebrafish related to mammalian Fluorescent Granular Perithelial (FGP) cells emerges directly from endothelium during early development.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez et al.
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Neuroscience

    Astrocyte morphology is confined by cortical functional boundaries in mammals ranging from mice to human

    Raya Eilam et al.
    The structural morphology of astrocyte processes is constrained by functional boundaries in the mouse, rat and human cortex.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Cell Biology
    2. Developmental Biology

    Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

    Kasmir Ramo et al.
    The kinase JNK is required in endothelial cells for the development of native collateral arteries.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

    Claudio A Franco et al.
    A threshold level of blood flow initiates developmental blood vessel regression; this threshold can be regulated by non-canonical Wnt ligands.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz et al.
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.

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