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Imaging studies of connexin-coupled networks of colorectal cancer cells reveal that cells carrying a genetic defect in an essential metabolic pathway can be rescued by diffusive exchange with neighboring wild-type cells via gap junctions, particularly Cx26, thereby evading negative selection.

Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.

The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.

To generate stable and robust connectivity refinements, the amplitude of spontaneous activity events in the developing visual cortex adapts to the recent history of cortical activation.

Inhibition provides a means for achieving temporal precision for rapid modulation of an acoustic signal in a vertebrate vocal network.

Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.

Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.

The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.

The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.

Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.