1,166 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta et al.
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu et al.
    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.
    1. Computational and Systems Biology

    Mitochondrial dysfunction remodels one-carbon metabolism in human cells

    Xiaoyan Robert Bao et al.
    Mitochondrial respiratory chain dysfunction inhibits mitochondrial one-carbon metabolism, impairing cellular nucleotide biosynthesis.
    1. Cancer Biology

    Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

    Volkan I Sayin et al.
    Activation of the NRF2 antioxidant program leads to an imbalance in central carbon metabolism and sensitizes cancers to glutaminase inhibition.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Computational and Systems Biology

    Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

    Ritu Gupta, Sunil Laxman
    A theoretical conceptualization of how phosphates control metabolic information flow and predictably regulate the metabolic state of the cell.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift et al.
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

    Anna M Puszynska, Erin K O'Shea
    The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al.
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke et al.
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.

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