57 results found
    1. Microbiology and Infectious Disease

    Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

    Patpicha Arunsan et al.
    Gene knockout of liver fluke granulin by CRISPR/Cas9 attenuates the virulence of infection with a carcinogenic liver fluke.
    1. Cancer Biology
    2. Cell Biology

    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Magda Spella et al.
    Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
    1. Cancer Biology

    Oncogene Regulation: Enhancers not required

    Ying Zheng, David Levens
    Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still thrive in the absence of stress.
    Insight
    Available as:
    • HTML
    • PDF
    1. Developmental Biology

    Genetic Diseases: Many ways to break a heart

    Megan Rowton, Ivan P Moskowitz
    Insight
    Available as:
    • HTML
    • PDF
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Point of View: Biological causal links on physiological and evolutionary time scales

    Amit Karmon, Yitzhak Pilpel
    Increasing awareness that many causal links in biology might be bi-directional could overcome biases and improve scientific reasoning.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbiome: Does disease start in the mouth, the gut or both?

    Andrei Prodan et al.
    Oral bacteria colonize the gut more frequently than previously thought.
    Insight
    Available as:
    • HTML
    • PDF
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Preclinical murine tumor models: a structural and functional perspective

    Marion V Guerin et al.
    Dissecting structural, cellular and molecular differences between transplanted and spontaneous mouse tumor models, highlighting their relevance for predicting the efficacy of anti-cancer treatments in patients.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.

Refine your results by:

Type
Research categories