Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.

The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.

Gene knockout of liver fluke granulin by CRISPR/Cas9 attenuates the virulence of infection with a carcinogenic liver fluke.

A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.

MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.

Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.

Inhaled fine particulate matters impair immune defense to accelerate tumorigenesis by pulling the strings of interstitial collagen in lung tissue.

A supervised methodology for mutational signatures outperforms the current standard unsupervised approach revealing new tissue-dependent mutational signatures among which some for obesity.

NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.