309 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    YAP drives cutaneous squamous cell carcinoma formation and progression

    Zoé Vincent-Mistiaen et al.
    High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang et al.
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

    Rigney E Turnham et al.
    Fibrolamellar carcinoma results from a genetic lesion that produces the DNAJ-PKAc fusion kinase, which is recruited into macromolecular complexes and is sensitive to combinations of signal transduction inhibitor drugs.
    1. Cancer Biology
    2. Immunology and Inflammation

    NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

    SM Nashir Udden et al.
    NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Cancer Biology

    Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

    John Repass, Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Cancer Biology
    2. Human Biology and Medicine

    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

    Alessia Calcagnì et al.
    Kidney-specific TFEB overexpression in transgenic mice closely recapitulates features observed in both TFEB- and TFE3-mediated human kidney tumors.
    1. Cancer Biology
    2. Human Biology and Medicine

    Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

    Andrew L Hong et al.
    Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.

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