480 results found
    1. Cancer Biology
    2. Genetics and Genomics

    Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

    Annie Wai Yeeng Chai et al.
    Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

    Rigney E Turnham et al.
    Fibrolamellar carcinoma results from a genetic lesion that produces the DNAJ-PKAc fusion kinase, which is recruited into macromolecular complexes and is sensitive to combinations of signal transduction inhibitor drugs.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang et al.
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.
    1. Cancer Biology

    The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

    Jacob T Polaski et al.
    UPF1 mutations were reportedly present at high frequencies in a cohort of pancreatic adenosquamous carcinoma patients, but these lesions are unlikely to be functional drivers of this cancer subtype.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Cancer Biology

    Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

    Andrew L Hong et al.
    Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    YAP drives cutaneous squamous cell carcinoma formation and progression

    Zoé Vincent-Mistiaen et al.
    High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Cancer Biology

    Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

    Nataša Pavlović et al.
    Inhibiting IRE1α decreases tumor cell proliferation and migration in hepatocellular carcinoma, therefore components of this ER-stress pathway may be therapeutically relevant for liver cancer.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer et al.
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.

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