NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.
The crystal structure of a mammalian protein kinase G reveals contacts between the regulatory and catalytic domains, indicates how cGMP binding alters domain conformations and thus domain:domain interactions, and informs a model for enzyme auto-inhibition and cooperative activation.
For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
Behavioural evidence and computational analyses suggest that people tend to decline the pursuit of more rewarded goals because they, wrongly, expect them to require more effortful actions.
