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Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.

Studies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.

Lack of cardiac MKK6 results in premature death with the development of heart hypertrophy and cardiac dysfunction in aging.

Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.

The heart is able to sense and adaptively respond to environmental changes due to cardiac injury through flow-mediated mechanisms that regulate cardiomyocyte reprogramming and regeneration.

At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.

Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.

Cardiac progenitors remain undifferentiated and expansive in the second pharyngeal arch that serves as a microenvironment, and Numb and Numblike are required for their renewal.

Human subjects actively adjust the acquisition of sense data based on how their bodily cycles alter their senses, i.e., sensing tactile stimuli for longer periods when concurrent physiological signals are present vs. sensing for shorter periods when these are quiescent.

Excitability gradients in heart tissue, imposed by structured sub-threshold optogenetic stimulation, induce drift and termination of spiral waves, thus providing an explanation for successful optogenetic defibrillation in small animal hearts.