624 results found
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology

    Evolution: The beat goes on

    Tobias Wang
    Why is the alligator heart so similar to the hearts of birds and mammals?
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  1. Peer Review: Decisions, decisions

    Peter Rodgers
    Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences.
    1. Human Biology and Medicine

    Adverse Drug Reactions: The benefits of data mining

    Audrey Bone, Keith Houck
    Careful analysis of a database populated by physicians and patients sheds new light on the side effects of drugs.
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    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Cancer: How does doxorubicin work?

    Anand G Patel, Scott H Kaufmann
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    1. Structural Biology and Molecular Biophysics

    Ion Channels: Exploiting natural regulation

    Catherine Proenza
    Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .
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    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Cardiac Hypertrophy: A tail of translational regulation

    Gillian A Gray, Nicola K Gray
    An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
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