190 results found
    1. Medicine

    Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

    Qiankun Bao et al.
    Targeting STAT3 provides a potential therapeutic strategy for obstructive sleep apnea-related fibrotic heart disease mediated by TSP1.
    1. Developmental Biology

    The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling

    Manon Destalminil-Letourneau et al.
    Two niches contribute to the control of Drosophila blood cell homeostasis through their differential regulation of hematopoietic progenitors.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+ epicardial cells

    Na Li et al.
    Brain natriuretic peptide supplementation can increase cardiac neovascularization in infarcted hearts by stimulating endogenous endothelial cell proliferation and proliferation of precursor cells, which will differentiate into endothelial cells.
    1. Chromosomes and Gene Expression
    2. Medicine

    A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

    Jefferson J Doyle et al.
    Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

    Laura Alonso-Herranz et al.
    Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.
    1. Developmental Biology

    Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

    Sweta Parab et al.
    Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.
    1. Developmental Biology

    Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming

    Manuel Gálvez-Santisteban et al.
    The heart is able to sense and adaptively respond to environmental changes due to cardiac injury through flow-mediated mechanisms that regulate cardiomyocyte reprogramming and regeneration.
    1. Developmental Biology

    NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

    Romaric Bouveret et al.
    Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra et al.
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.

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