Yfat Yahalom-Ronen, Dana Rajchman ... Eldad Tzahor
Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.
Rebeca San Martin, Priyojit Das ... Rachel Patton McCord
Age-stratified comparisons of gene expression in progeria patient fibroblasts reveals disruption of mesenchymal lineage pathways and points to a deficit in chondrogenic commitment in early development and a depletion of the mesenchymal lineage stem cell pool.
Comparative analysis of cardiac mitogenic pathways identified a potent human gene that is effective at driving in vitro cell cycle activation across species and cell culture systems.
Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.
Spatio-temporal analysis using live imaging in zebrafish reveals mural cells as a source of pro-lymphangiogenic factors including chemokine and growth factor signalling, necessary for robust lymphatic endothelial cell migration and survival.
Tim DD Somerville, Giulia Biffi ... Christopher R Vakoc
A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.
