292 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

    Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
    Networked cardiac control, revealed through analysis of extended baseline-state multi-channel recordings, differentiates heart failure and normal regimes highlighting the promise of peripheral neurally based clinical interventions.
    1. Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel, Natalia Färber ... Florian Beissner
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Cell Biology
    2. Developmental Biology

    Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

    Fabrice Bouilloux, Jérôme Thireau ... Frédéric Marmigère
    The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
    1. Evolutionary Biology

    Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

    Ana B Tinoco, Antón Barreiro-Iglesias ... Maurice R Elphick
    Starfish feed by everting their stomach out of their mouth over prey and, interestingly, this unusual feeding mechanism is inhibited by substances similar to hormones that regulate feeding in humans.
    1. Neuroscience

    Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia

    Vijayendran Chandran, Kun Gao ... Daniel H Geschwind
    Restoration of endogenous frataxin levels reverses neurologic and cardiac phenotypes associated with Friedreich's ataxia in adult mice even after significant motor dysfunction.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees, Jun-Hai Yang ... Alain Karma
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
    1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi
    Functional assays using zebrafish reveal that various microbial channelrhodopsins, guanylyl cyclase rhodopsin, and photoactivated adenylyl cyclases function as potent optogenetic tools, effectively controlling neural activity and cardiac function in zebrafish.
    1. Neuroscience

    Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH

    Jessica A Haley, David Hampton, Eve Marder
    The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
    1. Immunology and Inflammation
    2. Medicine

    Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

    Alex Moshensky, Cameron S Brand ... Laura E Crotty Alexander
    Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.
    1. Medicine
    2. Neuroscience

    The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

    Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt
    Transcutaneous auricular vagus nerve stimulation is a safe neuromodulatory treatment for subarachnoid hemorrhage patients, with potential benefits for restoring autonomic balance.

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