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    1. Neuroscience

    Unexpected arousal modulates the influence of sensory noise on confidence

    Micah Allen, Darya Frank ... Geraint Rees
    Changes in physiological arousal – as revealed by pupil dilation and heart rate – shape our confidence in decisions about uncertain perceptual information.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus, John P Incardona ... Sissel Jentoft
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Cell Biology

    Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

    Ienglam Lei, Shuo Tian ... Zhong Wang
    An acetyl-CoA-mediated metabolic and epigenetic network has been elucidated that stimulates histone acetylation and anti-oxidative stress gene expression for heart repair after myocardial infarction.
    1. Developmental Biology
    2. Neuroscience

    Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

    Yanshu Wang, Mark F Sabbagh ... Jeremy Nathans
    Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
    1. Medicine

    Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

    Alexandra Polyák, Leila Topal ... András Varró
    Vigorous endurance training results in prolongation of cardiac repolarization and increased repolarization instability, mild ventricular fibrosis associated with decrease of the transient outward potassium current, and enhanced arrhythmia susceptibility in canine model.
    1. Developmental Biology
    2. Medicine

    Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

    Jingyi Chi, Zeran Lin ... Paul Cohen
    The regulation of sympathetic innervation density by beige adipocytes in subcutaneous fat is important during a critical developmental window, but dispensable during adulthood.
    1. Developmental Biology

    Evolution: The beat goes on

    Tobias Wang
    Why is the alligator heart so similar to the hearts of birds and mammals?
    Version of Record
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova, Daniel E Sturdevant ... Alexander G Pletnev
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Developmental Biology

    Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate

    Silja Barbara Burkhard, Jeroen Bakkers
    A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.
    1. Structural Biology and Molecular Biophysics

    A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

    Andrea Saponaro, Francesca Cantini ... Anna Moroni
    Cell-penetrating peptide drugs prevent adrenergic regulation of pacemaker channels without altering the overall response of the cell to cAMP.