An expandable cell population derived from human pluripotent stem cells exhibits properties of mesoderm and is restricted to differentiate into derivatives of intermediate mesoderm.
Almary Guerra, Raoul FV Germano ... Sven Reischauer
A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
Nguyen Thi Thuy Ngan, Nhat Thanh Hoang Le ... Jeremy N Day
Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.
The miR-34/449 family is abundantly expressed in the central nervous system, and fine-tunes optimal numbers of spinal interneurons to ensure sensory-motor circuit outputs.
Alexander J Tarashansky, Jacob M Musser ... Bo Wang
Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.
PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
